Projects

Trastuzumab is a monoclonal antibody used for targeted breast cancer treatment. The production of the monoclonal antibody, trastuzumab, by the yeast Komagataella phaffii (Pichia pastoris) production system is being studied by INRAE - TWB. The expression of the genes coding heavy and light chain of the antibody is controlled by two ethanol inducible promoters.

Scorpionism is a serious public health problem in tropical areas, especially in Africa, southern India, the Middle East, and Latin America. There are about 12 species of scorpions that are dangerous to humans and all belong to the Buthidae family. In particular, venom on scorpion Androctonus australis hector is particularly toxic to humans. Serotherapy uses antibodies or fragments of antibodies to target the neurotoxins of the scorpion venom. Nanobodies, camelid-derived antibodies, are more ...